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KMID : 1143620150190010067
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Korean Journal of Nuclear Medicine Technology
2015 Volume.19 No. 1 p.67 ~ p.71
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Evaluation about Distribution of 18F-DOPA at Striatum by Using Dynamic Study
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Kim Jae-Il
Lee Hong-Jae
Kim Jin-Eui
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Abstract
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Purpose : At recently, we enter into the aging society and a age-related disease is increasing. Among that, prevalence of
degenerative brain disease like Parkin's disease will be increased. So, many radiopharmaceuticals is developed to diagnosis early and to evaluate the performance of therapeutic drugs. Especially 18F-DOPA which involved at dopamine synthesis and function of storage is widely used to the diagnosis of Parkinson's disease as well as brain tumors. in the study, we will evaluate the distribution pattern of 18F-DOPA at the striatum by using dynamic study.
Materials and Methods : We used Biograph Truepoint(Siemens, Germany) as PET/CT scanner, injected a 18F-DOPA (600±30 MBq) to patient (4men, 6women. 67±11 age) who visited our hospital from June to September, started 95min dynamic
study at same time. after finishing acquisition, we reconstructed PET data with 19 frame every 5 minutes, analysed a average counts at ROI's where set at both striatums, anterior putamen, posterior putamen
Results : Counts in the cerebellum as the background formed a plateau after 90 minutes from the highest out rapidly
reduced to 15 minutes. Counts of anterior putamen and posterior gradually increased but formed a plateau after 60min. A count ratio of Striatum to cerebellum was continuously increased up to more than 95 minutes, A count ratios of an anterior putamen to posterior one formed a plateau after 85 minutes.
Conclusion : The dynamic acquisition can be possible to evaluate a distribution of the 18F-DOPA in the striatum and the VOI analysis through a dynamic acquisition and a variety of patterns. Futhermore, to make a uniformed distribution
and count ratio of striatum to cerebellum, a static acquisition will have to start 90minutes later after injection.
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KEYWORD
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18F-DOPA, Parkinson’s Disease, dynamic study, VOI, Striatum
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